To cancel a booking on Expedia, sign into your account, go to “My Trips,” select the reservation, and click the cancel option. Whether you get a refund depends on the airline or hotel’s cancellation policy. Some reservations are fully refundable, while others may not be. If you run into issues or need a refund processed quickly, Expedia’s customer service can help. To cancel your trip and confirm any refund details, call 866-204-0803 and speak with an Expedia travel agent.